The most frequently diagnosed endocrine cancer, which causes more deaths than any other endocrine cancer, is thyroid cancer. Cancer stem cells are rare cells found in tumors that can regenerate themselves, phenotypically leads to various tumor cell populations and trigger tumorigenesis. Cancer stem cells have been identified in many cancers, including thyroid cancer. Having an understanding of the molecular mechanisms which control the biology of cancer stem cells and the disease processes will help us in designing more rational targeted therapies for aggressive thyroid cancers. In this review, we aimed to present the current accepted knowledge about thyroid stem cells, information regarding the cellular origin of thyroid cancer stem cells, and the clinical results of cancer stem cells present in the thyroid gland.
Hua J, Qiu P, Zhu H, Cao H, Wang F, Li W. Multipotent mesenchymal stem cells (MSCs) from human umbilical cord : Potential differentiation of germ cells. African J od Biochem Res. 2011;5(4):113–23.
Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006 Aug 25;126(4):663-76. DOI: 10.1016/j.cell.2006.07.024
Bhatia P, Tsumagari K, Abd Elmageed ZY, Friedlander P, Buell JF, Kandil E. Stem cell biology in thyroid cancer: Insights for novel therapies World J Stem Cells. 2014 Nov 26;6(5):614-9. DOI: 10.4252/wjsc.v6.i5.614
Lin RY. Thyroid cancer stem cells. Nat Rev Endocrinol. 2011 Jul 26;7(10):609-16. DOI: 10.1038/nrendo.2011.127
Nagayama Y, Shimamura M, Mitsutake N. Cancer stem cells in the thyroid. Front Endocrinol (Lausanne). 2016 Feb 29;7:20. DOI: 10.3389/fendo.2016.00020
Antonelli A, La Motta C. Novel Therapeutic Clues in Thyroid Carcinomas: The Role of Targeting Cancer Stem Cells. Med Res Rev. 2017 Nov;37(6):1299-1317. DOI: 10.1002/med.21448
Dumont JE, Lamy F, Roger P, Maenhaut C. Physiological and pathological regulation of thyroid cell proliferation and differentiation by thyrotropin and other factors. Physiol Rev. 1992 Jul;72(3):667-97. DOI: 10.1152/physrev.1922.214.171.1247
Thomas T, Nowka K, Lan L, Derwahl M. Expression of endoderm stemcell markers: evidence for the presence of adult stem cells in human thyroid glands. Thyroid. 2006 Jun;16(6):537-44. DOI: 10.1089/thy.2006.16.537
Hoshi N, Kusakabe T, Taylor BJ, Kimura S. Side population cells in the mouse thyroid exhibit stem/ progenitorcell-like characteristics. Endocrinology. 2007 Sep;148(9):4251-8. DOI: 10.1210/en.2006-0490
Lan L, Cui D, Nowka K, Derwahl M. Stem cells derived from goiters in adults form spheres in response to intense growth stimulation and require TSH for differentiation into thyrocytes. J Clin Endocrinol Metab. 2007 Sep;92(9):3681-8. DOI: 10.1210/jc.2007-0281
Thomas D, Friedman S, Lin RY. Thyroid stemcells: lessons from normal development and thyroid cancer. Endocr Relat Cancer. 2008 Mar;15(1):51-8. DOI: 10.1677/ERC-07-0210
Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci. 2003 Apr 1;100(7):3983–8. DOI: 10.1073/pnas.0530291100
Zhang P, Zuo H, Ozaki T, Nakagomi N, Kakudo K. Cancer stem cell hypothesis in thyroid cancer. Pathol Int. 2006 Sep;56(9):485-9. DOI: 10.1111/j.1440-1827.2006.01995.x
Takano T, Amino N. Fetal cell carcinogenesis: a new hypothesis for better understanding of thyroid carcinoma. Thyroid. 2005 May;15(5):432-8. DOI: 10.1089/thy.2005.15.432
Quintana E, Shackleton M, Sabel MS, Fullen DR, Johnson TM, Morrison SJ. Efficient Tumour Formation by Single Human Melanoma Cells. Nature. 2008 Dec 4;456(7222):593-8. DOI: 10.1038/nature07567
Schatton T, Murphy GF, Frank NY, Yamaura K, Waaga-Gasser AM, Gasser M et al. Identification of cells initiating melanomas. Nature. 2008 Jan 17;451(7176):345-9. DOI: 10.1038/nature06489
Antonica F, Kasprzyk DF, Opitz R, Iacovino M, Liao XH, Dumitrescu AM, et al. Generation of functional thyroid from embryonic stem cells. Nature. 2012 Nov 10;491(7422):66–71. DOI: 10.1038/nature11525
Zane M, Scavo E, Catalano V, Bonanno M, Todaro M, De Maria R et al. Normal vs cancer thyroid stem cells: the road to transformation. Oncogene. 2016 Feb 18;35(7):805-15. DOI: 10.1038/onc.2015.138
Shimamura M, Nagayama Y, Matsuse M, Yamashita S, Mitsutake N.
Analysis of multiple markers for cancer stem-like cells in human thyroid carcinoma cell lines. Endocr J. 2014;61(5):481-90. DOI: 10.1507/endocrj.ej13-0526
Guo Z, Hardin H, Lloyd RV. Cancer stem-like cells and thyroid cancer. Endocr Relat Cancer. 2014 ;21(5):T285-300. DOI: 10.1530/ERC-14-0002
Singh SK, Hawkins C, Clarke ID, Squire JA, Bayani J, Hide T, et al. Identification of human brain tumour initiating cells. Nature. 2004 Nov 18;432(7015):396–401. DOI: 10.1038/nature03128
Tseng LM, Huang PI, Chen YR, Chen YC, Chou YC, Chen YW, et al. Targeting signal transducer and activator of transcription 3 pathway by cucurbitacin I diminishes self-renewing and radiochemoresistant abilities in thyroid cancer-derived CD133+ cells. J Pharmacol Exp Ther. 2012 May;341(2):410-23. DOI: 10.1124/jpet.111.188730
Giani F, Vella V, Nicolosi ML, Fierabracci A, Lotta S, Malaguarnera R, et al. Thyrospheres From Normal or Malignant Thyroid Tissue Have Different Biological, Functional, and Genetic Features. J Clin Endocrinol Metab. 2015 Sep;100(9):E1168-78. DOI: 10.1210/JC.2014-4163
Lan L, Luo Y, Cui D, Shi BY, Deng W, Huo LL et al. Epithelial-mesenchymal transition triggers cancer stem cell generation in human thyroid cancer cells. Int J Oncol. 2013 Jul;43(1):113-20. DOI: 10.3892/ijo.2013.1913
Chaffer CL, Weinberg RA. A perspective on cancer cell metastasis. Science. 2011 Mar 25;331(6024):1559-64. DOI: 10.1126/science.1203543
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