Keywords
Varicose Vein
Tissue Adhesive
Tissue Sealant
Tissue Glue
How to Cite
Abstract
Purpose: Chronic venous disease (CVD) has an excellent socioeconomic impact. Treatment modalities of CVD are evolving fields that could be derived from the disease's progressive nature.
Materials and methods: After a wide literature search in Google Scholar (Publish and Perish software), extracted data was analyzed by VOSviewer software, creating network and overlay visualizations.
Results: CVD has been investigated intensively in the literature from the beginning of the 21st century. Studies aimed to understand the mechanism of CVD in the early 2000s. Later, the focus of scientific interest was moved to novel procedures. Researchers were motivated to explore the reasons for technical failures and recurrences of endovenous thermal ablation (EVTA) procedures and open surgery to treat saphenous incompetence. Less invasive procedures replaced invasive open surgery. The search for novel tissue sealants showed a thin centralized network. Papers were dated from 2010. Therefore, this is a very recent source of evidence. There were meeting points for some components of tissue sealants. Biomaterials for novel tissue adhesion are under development and investigation. The efficacy and safe application in humans is the focus of research.
Conclusion: Researchers widely investigate CVD. An evolution from invasive open surgery (stripping) through EVTA to non-thermal ablation procedures could be discovered in the literature. There could be some versatile options for replacing cyanoacrylate in the future, but there are no clear paths to reach that point in scientific literature yet.
References
Wrona M, Jöckel KH, Pannier F, Bock E, Hoffmann B, Rabe E. Association of Venous Disorders with Leg Symptoms: Results from the Bonn Vein Study 1. Eur J Vasc Endovasc Surg. 2015;50(3):360-7. https://doi.org/10.1016/j.ejvs.2015.05.013
Robertson LA, Evans CJ, Lee AJ, Allan PL, Ruckley CV, Fowkes FG. Incidence and risk factors for venous reflux in the general population: Edinburgh Vein Study. Eur J Vasc Endovasc Surg. 2014;48(2):208-14. https://doi.org/10.1016/j.ejvs.2014.05.017
Lattimer CR. CVD: a condition of underestimated severity. Int Angiol. 2014;33(3):222-8. Available from: https://pubmed.ncbi.nlm.nih.gov/24732585/
Rabe E, Guex JJ, Puskas A, Scuderi A, Fernandez Quesada F. The VCP Coordinators. Epidemiology of chronic venous disorders in geographically diverse populations: results from the Vein Consult Program. Int Angiol. 2012;31(2):105-15. Available from: https://pubmed.ncbi.nlm.nih.gov/22466974/
Margolis DJ, Bilker W, Santanna J, Baumgarten M. Venous leg ulcer: incidence and prevalence in the elderly. J Am Acad Dermatol. 2002; 46: 381-6. http://dx.doi.org/10.1067/mjd.2002.121739
Marston WA. Evaluation of varicose veins: what do the clinical signs and symptoms reveal about the underlying disease and need for intervention? Semin Vasc Surg. 2010;23(2):78-84. https://doi.org/10.1053/j.semvascsurg.2010.01.003
Antani MR, Dattilo JB. Varicose Veins. PubMed. Treasure Island (FL): StatPearls Publishing; 2020. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470194/ .
Rabe E, Pannier F. What is evidence-based in the treatment of chronic venous insufficiency? Internist (Berl). 2020;61(12):1230-1237. https://doi.org/10.1007/s00108-020-00899-6
Vuylsteke ME, Klitfod L, Mansilha A. Endovenous ablation. Int Angiol. 2019;38(1):22-38. https://doi.org/10.23736/S0392-9590.18.04047-6
Oliveira RÁ, Mazzucca ACP, Pachito DV, Riera R, Baptista-Silva JCDC. Evidence for varicose vein treatment: an overview of systematic reviews. Sao Paulo Med J. Jul-Aug 2018;136(4):324-332. https://doi.org/10.1590/1516-3180.2018.0003240418
van den Bos RR, Proebstle TM. The state of the art of endothermal ablation. Lasers Med Sci. 2014 Mar;29(2):387-92. https://doi.org/10.1007/s10103-013-1448-5
Kolluri R. Interventions for Varicose Veins: Beyond Ablation. Curr Treat Options Cardiovasc Med. 2016;18(7):43. https://doi.org/10.1007/s11936-016-0467-5
Bootun R, Lane TR, Davies AH. The advent of non-thermal, non-tumescent techniques for treatment of varicose veins. Phlebology. 2016;31(1):5-14. https://doi.org/10.1177/0268355515593186
Whiteley MS. Glue, steam and Clarivein--Best practice techniques and evidence. Phlebology. 2015;30(2 Suppl):24-8. https://doi.org/10.1177/0268355515591447
McHugh SM, Leahy AL. What next after thermal ablation for varicose veins: non-thermal ablation? Surgeon. 2014;12(5):237-8. https://doi.org/10.1016/j.surge.2014.06.003
Tang TY, Yap CJQ, Chan SL, Soon SXY, Yap HY, Lee SQW, Choke ETC, Chong TT. Early results of an Asian prospective multicenter VenaSeal real-world postmarket evaluation to investigate the efficacy and safety of cyanoacrylate endovenous ablation for varicose veins. J Vasc Surg Venous Lymphat Disord. 2021;9(2):335-345.e2. https://doi.org/10.1016/j.jvsv.2020.03.020
Morrison N, Gibson K, Vasquez M, Weiss R, Jones A. Five-year extension study of patients from a randomized clinical trial (VeClose) comparing cyanoacrylate closure versus radiofrequency ablation for the treatment of incompetent great saphenous veins. J Vasc Surg Venous Lymphat Disord. 2020;8(6):978-989. https://doi.org/10.1016/j.jvsv.2019.12.080
Kolluri R, Chung J, Kim S, Nath N, Bhalla BB, Jain T, Zygmunt J, Davies A. Network meta-analysis to compare VenaSeal with other superficial venous therapies for chronic venous insufficiency. J Vasc Surg Venous Lymphat Disord. 2020;8(3):472-481.e3. https://doi.org/10.1016/j.jvsv.2019.12.061
Parsi K, Roberts S, Kang M, Benson S, Baker L, Berman I, Bester LJ, Connor DE, Dinnen P, Grace J, Stirling A, Ibrahim N, Lekich C, Lim A, Matar L, Nadkarni S, Paraskevas P, Rogan C, Thibault PK, Thibault S, van Rij A, Yang A. Cyanoacrylate closure for peripheral veins: Consensus document of the Australasian College of Phlebology. Phlebology. 2020;35(3):153-175. https://doi.org/10.1177/0268355519864755
Morrison N, Gibson K, Vasquez M, Weiss R, Cher D, Madsen M, Jones A. VeClose trial 12-month outcomes of cyanoacrylate closure versus radiofrequency ablation for incompetent great saphenous veins. J Vasc Surg Venous Lymphat Disord. 2017;5(3):321-330. https://doi.org/10.1016/j.jvsv.2016.12.005
Vos CG, Ünlü Ç, Bosma J, van Vlijmen CJ, de Nie AJ, Schreve MA. A systematic review and meta-analysis of two novel techniques of nonthermal endovenous ablation of the great saphenous vein. J Vasc Surg Venous Lymphat Disord. 2017 Nov;5(6):880-896. https://doi.org/10.1016/j.jvsv.2017.05.022. Epub 2017 Jul 21. PMID: 29037363 Review.J Vasc Surg Venous Lymphat Disord. 2017;5(6):880-896. https://doi.org/10.1016/j.jvsv.2017.05.022
Harzing AW. Publish or Perish. 2016. Available from https://harzing.com/resources/publish-or-perish
Bihari I. Az alsó végtagi varicositas műtéti eltávolításának módszerei. Érbetegségek. 1999;6(2):55-66. http://dx.doi.org/10.1556/650.2018.31262
Milleret R., Le Pivert P. Cryosclerosis of the saphenous veins in varicose reflux in the obese and elderly. Phlebologie. 198;34(4):601-5. https://pubmed.ncbi.nlm.nih.gov/7335776/
Weiss RA, Weiss MA. Controlled radiofrequency endovenous occlusion using a unique radiofrequency catheter under duplex guidance to eliminate saphenous varicose vein reflux: a 2-year follow-up. Dermatol Surg. 2002;28(1):38-42. http://dx.doi.org/10.1046/j.1524-4725.2002.01188.x
Goldman MP, Amiry S. Closure of the greater saphenous vein with endoluminal radiofrequency thermal heating of the vein wall in combination with ambulatory phlebectomy: 50 patients with more than 6-month follow-up. Dermatol Surg. 2002;28(1):29-31. http://dx.doi.org/10.1046/j.1524-4725.2002.01187.x
Weiss RA. Comparison of endovenous radiofrequency versus 810 nm diode laser occlusion of large veins in an animal model. Dermatol Surg. 2002;28(1):56-61. http://dx.doi.org/10.1097/00042728-200201000-00013
Min RJ, Zimmet SE, Isaacs MN, Forrestal MD. Endovenous laser treatment of the incompetent greater saphenous vein. J Vasc Interv Radiol. 2001;12(10):1167-71. http://dx.doi.org/10.1016/S1051-0443(07)61674-1
Navarro L, Min RJ, Boné C. Endovenous laser: a new minimally invasive method of treatment for varicose veins--preliminary observations using an 810 nm diode laser. Dermatol Surg. 2001;27(2):117-22. http://dx.doi.org/10.1046/j.1524-4725.2001.00134.x
Goldman MP. Closure of the greater saphenous vein with endoluminal radiofrequency thermal heating of the vein wall in combination with ambulatory phlebectomy: preliminary 6-month follow-up. Dermatol Surg. 2000;26(5):452-6.
Kanter A. Clinical determinants of ultrasound-guided sclerotherapy. Part II: In search of the ideal injectate volume. Dermatol Surg. 1998;24(1):136-8; discussion 138-40. http://dx.doi.org/10.1016/S1076-0512(98)00457-9
Kanter A. Clinical determinants of ultrasound-guided sclerotherapy outcome. Part I: The effects of age, gender, and vein size. Dermatol Surg. 1998;24(1):131-5. http://dx.doi.org/10.1016/S1076-0512(97)00456-1
Nicolaides A, Kakkos S, Baekgaard N, Comerota A, de Maeseneer M, Eklof B, et al. Management of chronic venous disorders of the lower limbs. Guidelines According to Scientific Evidence. Part II. Int Angiol. 2020;39(3):175-240. https://doi.org/10.23736/S0392-9590.20.04388-6
Wittens C, Davies AH, Bækgaard N, Broholm R, Cavezzi A, Chastanet S, et al. Editor's Choice - Management of Chronic Venous Disease: Clinical Practice Guidelines of the European Society for Vascular Surgery (ESVS). Eur J Vasc Endovasc Surg. 2015;49(6):678-737. https://doi.org/10.1016/j.ejvs.2015.02.007
Gloviczki P, Comerota AJ, Dalsing MC, Eklof BG, Gillespie DL, Gloviczki ML, et al. Society for Vascular Surgery; American Venous Forum. The care of patients with varicose veins and associated chronic venous diseases: clinical practice guidelines of the Society for Vascular Surgery and the American Venous Forum. J Vasc Surg. 2011;53(5 Suppl):2S-48S. https://doi.org/10.1016/j.jvs.2011.01.079
Gillman N, Lloyd D, Bindra R, Ruan R, Zheng M. Surgical applications of intracorporal tissue adhesive agents: current evidence and future development. Expert Rev Med Devices. 2020;17(5):443-460. https://doi.org/10.1080/17434440.2020.1743682
Bao Z, Gao M, Sun Y, Nian R, Xian M. The recent progress of tissue adhesives in design strategies, adhesive mechanism and applications. Mater Sci Eng C Mater Biol Appl . 2020;111:110796. https://doi.org/10.1016/j.msec.2020.110796
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