Purpose: Chronic venous disease (CVD) has an excellent socioeconomic impact. Treatment modalities of CVD are evolving fields that could be derived from the disease's progressive nature.
Materials and methods: After a wide literature search in Google Scholar (Publish and Perish software), extracted data was analyzed by VOSviewer software, creating network and overlay visualizations.
Results: CVD has been investigated intensively in the literature from the beginning of the 21st century. Studies aimed to understand the mechanism of CVD in the early 2000s. Later, the focus of scientific interest was moved to novel procedures. Researchers were motivated to explore the reasons for technical failures and recurrences of endovenous thermal ablation (EVTA) procedures and open surgery to treat saphenous incompetence. Less invasive procedures replaced invasive open surgery. The search for novel tissue sealants showed a thin centralized network. Papers were dated from 2010. Therefore, this is a very recent source of evidence. There were meeting points for some components of tissue sealants. Biomaterials for novel tissue adhesion are under development and investigation. The efficacy and safe application in humans is the focus of research.
Conclusion: Researchers widely investigate CVD. An evolution from invasive open surgery (stripping) through EVTA to non-thermal ablation procedures could be discovered in the literature. There could be some versatile options for replacing cyanoacrylate in the future, but there are no clear paths to reach that point in scientific literature yet.
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