Priapism in the Context of Sickle Cell Disease: State of the Art and Perspectives


Sickle cell disease

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Bakkali Aissaoui Z, Kharbach Y, EL Hichou EM, Khallouk A. Priapism in the Context of Sickle Cell Disease: State of the Art and Perspectives. Surg Insights [Internet]. 2024 Jun. 15 [cited 2024 Jul. 19];. Available from:


Priapism is a frequent complication in patients with sickle cell disease, putting their sexual and reproductive health at risk. This systematic review aims to analyze existing studies on priapism in this context comprehensively. The results show that priapism, particularly the ischaemic type, is prevalent in men with sickle cell disease, especially those carrying HbSS genotypes. Risk factors include vaso-occlusive crises, severe anemia, infections, and dehydration. Pathophysiological mechanisms involve endothelial dysfunction, vasoconstriction, local hypoxia, and inflammation. Diagnosis is based on clinical assessment and investigations such as penile Doppler ultrasound. Treatments include conservative measures, aspiration of the corpora cavernosa, intracavernous injections of vasoconstrictors, and surgical shunts. Prevention involves specific management of sickle cell anemia, with regular monitoring and raising awareness among the general public. This review highlights the clinical challenges of priapism in sickle cell disease and underlines the importance of a multidisciplinary approach to improve care and quality of life for affected patients.


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Copyright (c) 2022 Bakkali Aissaoui Z et al.


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